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ISG15/ISGylation: Interferons α and β (IFN-α/β) are crucial effectors of the innate immune system. Numerous studies confirmed these data and the investigation of the link between metabolic transformation and cellular reprogramming is presently an active field of research. Institute for Theoretical Biology (ITB), Charité-CCM and Molecular Cancer Research Centre (MKFZ), Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum (CVK) Augustenburger Platz 1, 13353 Berlin 49 30 2093 6044 [email protected]: In my group we investigate the coupling of the circadian system to tumour progression. The role of CD8 T cells and their local interaction with CD4 T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitis. In contrast to rheumatoid arthritis, reactive new bone formation is commonly seen in Sp A - promoting impairment of spinal mobility and disability.
Engagement of the IFNA-receptor induces the expression of the IFN Stimulated Gene of 15 k Da (ISG15). I now wish to build employ the i PSC technology for advancing the understanding and treatment of debilitating brain disorders due to mitochondrial impairment. All cells hold an internal clock able to generate daily rhythms in gene expression and to adapt molecular processes to specific day-times. The first goal of our research is to understand the immunological dysfunction promoting the spinal and peripheral joint inflammation in Sp A.
Such research represents an essential step towards the identification of novel drug targets in the future. Hinz, M.*, Stilmann, M.* , Çöl Arslan, S., Khanna, K. A cytoplasmic ATM-TRAF6-c IAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. From a translational point of view, many innate immune functions are quite different between men and mice and many human pathogens are not naturally adapted to animals necessitating a stronger focus in the establishment of human disease models. 12-6 Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T: (2013) The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue. 8:e00601-13 Weinheimer VK, Becher A, Tonnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Ruckert JC, Szymanski K, Temmesfeld-Wollbrueck B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S., Wolff T, and Hocke A C: (2012) Influenza A viruses target type II pneumocytes in the human lung. Neuroregenerative / -protective action of Clostridium botulinum C3 Peptides for the treatment of spinal cord injuries (behavioural mouse models, histochemistry, light- / electron microscopy, activation status of molecular switches such as Rho-proteins, effects on neurotransmitter handling by radiolabelled transmitter assays) Investigation of molecular events contributing to the newly detected autoimmune diseases such as anti NMDA-receptor encephalitis, close cooperation with the Neurology department of the Charité (use of patients serum and CSF for investigation of effects on synaptic proteins in cell lines, primary neuronal culture and tissue culture). Group leader C3 Proteins and Neuronal Regeneration - Supervision of more than 10 Ph D and MD students - Conduction of the annual course “Functional and practical neuroanatomy for neurologists, neurosurgeons, neuroradiologists and psychiatrists” for eight years Prüss H.*, Höltje M.*, Maier N., Gomez A., Buchert R., Harms L., Ahnert - Hilger G., Schmitz D., Terborg C., Köller H., Kopp U., Klingbeil C., Borowski K., Kohler S., Schwab JM., Stoecker W., Dalmau J., Wandinger KP. Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs N, Schumann G, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z. With our research, we expect to be able to provide valuable insights into the mechanism of circadian regulation of tumourigenesis per se and to contribute to a better understanding of the cancer-clock system. The majority of these cells showed demethylation at a T regulatory cell specific demethylated region, indicating their functional imprinting and stability (Appel et al.). Brain Behav Immun 38, 175-184, (2014) Kristin Stock, Alexander Garthe, Felipe de Almeida Sassi, Rainer Glass, Susanne A.
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Initiated by entry-level scientists from MDC and Charité, BIH Young Science had its founding event in January 2014. These receptors include the Toll-like receptors (TLRs), the NOD-like receptors (NLRs), RIG-I-like receptors (RLRs) and cytosolic DNA sensors.
Cell (2012); 149(6):1393-406i My mission is to decipher cell-intrinsic immune mechanisms that on the one hand limit pathogen spread during viral infection and on the other hand ensure immune homeostasis for the benefit of the host. Am J Physiol Lung Cell Mol Physiol 28-84, 2007 Francis RC, Philippi-Höhne C, Klein A, Pickerodt PA, Reyle-Hahn MS, Boemke W.
We seek to use of evolutionary evolved endogenous effector pathways to fight susceptibility to infection. Xenon/remifentanil anesthesia protects against adverse effects of losartan on hemodynamic challenges induced by anesthesia and acute blood loss.
If you would like to contribute and become a part of the initiative, please fill in the CV form provided. We focus on infections with bacterial pathogens causing pneumonia including S. pneumophila, and Pseudomonas aeruginosa, and employ different in vivo and in vitro infection models.